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Choosing The Right Refill Design For Pharmaceutical Loss-In-Weight Feeders

Source: Coperion K-Tron

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Article: Choosing The Right Refill Design For Pharmaceutical Loss-In-Weight Feeders

By Sharon Nowak
Global Business Development Manager, Food/Pharmaceutical
K-Tron Process Group

As the pharmaceutical industry continues to investigate and utilize continuous manufacturing practices, the roles of loss-in-weight (LIW) feeders and the subsequent accurate and consistent refill of these feeders are critical to the overall process. The method of refill, reaction time of the refill device, and also the size of the refill hopper are all critical variables in ensuring an accurate and consistent flow of material to the LIW feeder.

A typical LIW feeder achieves rate control by weighing the entire feeder, hopper, and the material contained in it. The speed of the metering device is controlled to result in a per-unit-time loss of system weight equal to the feed rate. As an integral part of loss-in-weight feeding, the weighed hopper must be re-supplied with material. Several pharmaceutical operations are dependent upon this refill of feed principle. These operations include continuous extrusion (both hot-melt and wet granulation extrusion), continuous direct compression or blending, and continuous wet granulation.

Click Here To Download:
Article: Choosing The Right Refill Design For Pharmaceutical Loss-In-Weight Feeders